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BEST-2 and BEST 3 Trial images
The BEST 2/3 Trial images are a database of clinically-linked digitised pathology slides, generated during the BEST 2 and and BEST 3 clinical trials. (See https://www.mrc-cu.cam.ac.uk/research/rebecca-fitzgerald/clinical-studies/BEST2Folder and https://www.mrc-cu.cam.ac.uk/research/rebecca-fitzgerald/clinical-studies/BEST3, respectively.) These trials were aimed at testing the feasibility of a new sampling method known as the Cytosponge. The Cytosponge is pill on a string which dissolves to release a sponge that can then be removed to gather samples from the oesophagus, and it has proven to be a successful alternative to endoscopy testing for patients at high risk of developing oesophageal cancer. During these trials, 3350 patient samples were collected and stained using standard H&E techniques, with additional staining for oesophageal cancer-related biomarker TFF3, and they were subsequently digitised. In addition to the digitised slides, biopsy results and the outcomes of complementary endoscopy testing can be provided upon approval from our clinical collaborator. We would be happy to discuss non-exclusive licensing of these assets with companies in the digital pathology space or other related areas.