Cancer Research UK and Cancer Research Technology announce partnership with Monopar Therapeutics to develop new oncology compound

2015-07-09 00:00:00

Cancer Research UK and Cancer Research Technology (CRT) have reached agreement with Monopar Therapeutics LLC, an emerging biopharmaceutical company focused on developing orphan oncology compounds*, to take forward Monopar’s experimental antibody treatment HuATN-658 into clinical trials in cancer patients with advanced solid tumours.

HuATN-658 is an antibody that targets the cell surface protein uPAR, which is found in high levels in some of the most deadly cancers.

Under the agreement, Cancer Research UK’s Centre for Drug Development (CDD) will finance and complete preclinical development of HuATN-658 and conduct a Phase 1 clinical trial in cancer patients. Although drug efficacy will be monitored, the trial’s main objective will be to evaluate the safety of the antibody.

The trial will be managed and run by the CDD through the Experimental Cancer Medicine Centre (ECMC) network, a UK-wide initiative funded by Cancer Research UK and the UK’s four Health Departments.

Upon completion of the clinical trial, Monopar has the right to acquire the clinical trial data. If Monopar declines the option, CRT may continue the development and commercialisation of HuATN-658 in exchange for a share to Monopar of any future revenues from the drug.

Dr Chandler D. Robinson, co-founder and CEO of Monopar Therapeutics, said: “While these are still the early days of the company, we have created a very strong team and development strategy.

“HuATN-658, our lead compound, was discovered by our chief scientific officer, Dr Andrew Mazar, one of the world’s experts on the uPAR pathway.

“The development partnership with Cancer Research UK allows Monopar to leverage a strong platform for the clinical advancement of this compound as it brings long established clinical, regulatory, and manufacturing expertise and resources that would be difficult for an emerging company to amass quickly.”

Dr Nigel Blackburn, Cancer Research UK’s director of drug development, said, “We’re excited to be working with Monopar Therapeutics to take this promising new treatment a step further on its journey towards the clinic. The collaboration forms part of our Clinical Development Partnerships scheme, which aims to help progress promising treatments from drug company pipelines and bring them into early phase trials sooner. Thanks to this, six new treatments are now in clinical trials that may otherwise never have moved beyond the lab.”


Cancer Research UK\CRT: +44 (0) 203 469 8300. For out of hours duty press officer contact: +44 (0) 7050 264 059.

Monopar Therapeutics: Janine McCargo Tiberend Strategic Advisors (US): +01 646 605 5150

Notes to editors

*An orphan oncology compound is developed specifically to treat a rare cancer.

About Monopar Therapeutics

Monopar Therapeutics’ mission is to develop life-altering orphan oncology therapeutics.  Monopar was formed in 2014 as a privately-held company and has established a collaboration with Cancer Research - UK / Cancer Research Technology to develop Monopar's initial drug candidate HuATN-658, an anti-uPAR monoclonal antibody for the treatment of cancer.  In addition, Monopar is actively seeking to license or purchase clinical-stage oncology drug candidates for development and ultimately commercialization. For more information about Monopar Therapeutics visit

About Cancer Research Technology

Cancer Research Technology (CRT) is a specialist commercialisation and development company, which aims to develop new discoveries in cancer research for the benefit of cancer patients. CRT works closely with leading international cancer scientists and their institutes to protect intellectual property arising from their research and to establish links with commercial partners. CRT facilitates the discovery, development and marketing of new cancer therapeutics, vaccines, diagnostics and enabling technologies. CRT is a wholly owned subsidiary of Cancer Research UK, the world's leading cancer charity dedicated to saving lives through research. Further information about CRT can be found at

About Cancer Research UK


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