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- Novel tumour endothelial marker: antibody target for anti-angiogenesis approaches.
- Expression is highly restricted to tumour endothelial cells.
- Evidence of role in endothelial migration and tube formation.
- CLEC14A KO mice and inhouse generated murine monoclonal antibodies demonstrate in vivo tumor burden reduction and inhibition of invasion.
- Potential role as cancer biomarker.
- Intellectual property protected with two patent applications
Tumor endothelial markers (TEMs) that are highly expressed in human tumor vasculature compared with vasculature in normal tissue hold clear therapeutic potential. C-type lectin CLEC14A is a novel TEM, a transmembrane protein that is specifically expressed on the surface of tumour endothelial cells.
Prof. Roy Bicknell, Cancer Research UK Molecular Angiogenesis Group, University of Birmingham.
1. Mura M et al; Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene. 2011 Jun 27
2. Rho SS et al; Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion. Biochem Biophys Res Commun. 2011 Jan 7
3. Noy PJ et al; Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. Oncogene. 2015 Mar 9