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Small Molecules

Small molecule programmes focused on the development of inhibitors of novel cancer targets and pathways are available for co-development and/or licensing.

CRUK has developed a potent, selective and orally bioavailable series of small molecules inhibiting glutaminase (GLS), with superior developability.

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AZD3965 is a Phase 2 ready, first-in-class oral and highly selective inhibitor of MCT-1 that has shown promising signs of efficacy in early phase clinical trials in DLBCL.

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We have developed first-in-class IKKα selective compounds with in vivo data showing strong inhibition of tumour growth.

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We are seeking a commercial partner interested in pursuing a co-development or direct licensing arrangement.

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