Repurposed drug tested in COVID-19 trial, thanks to Cancer Research UK know-how

2020-05-29 00:00:00

Cancer Research UK and its partners have today (Friday) launched a clinical trial to test if a drug that’s used to treat inflammation of the pancreas can help people with COVID-19.

Cancer patients have been severely affected by COVID-19, impacting on how they are diagnosed, treated and cared for. Beating cancer remains Cancer Research UK’s priority, but the charity realises that it will not be able to fully focus on its mission until COVID-19 itself is under control and where possible, has been supporting the national effort, while still pushing forward with its mission to beat cancer.

Cancer Research UK’s Centre for Drug Development’s (CDD) involvement in the new SPIKE1 trial is an example of where the charity has been able to work with industry and academia. Rapidly responding and contributing to the COVID-19 effort, without redirecting efforts from cancer patients with the CDD still able to continue treatment for all cancer patients on their phase I trials.

The SPIKE1 trial, funded by LifeArc, is a partnership between the CDD, Latus Therapeutics and the University of Edinburgh. It will investigate whether a drug called camostat, which has been shown in the lab to prevent COVID-19 from entering human cells, could help control symptoms of the virus and prevent people that are infected needing to go to hospital. Camostat is already licensed in Japan and South Korea to treat pancreatic disease, so if successful it could be quickly manufactured and used to treat people with COVID-19.*

Almost half of UK COVID-19 patients requiring critical care have died in hospital so far.** Currently, there is a limited number of treatment options available for people affected by COVID-19, such as the recently approved antiviral drug remdesivir.

Scientists around the world are racing to find a vaccine against the killer virus, but even with the impressive progress seen so far, it will take time before an effective vaccine can safely be given to people. While the world waits for a vaccine, repurposing already available drugs such as remdesivir or camostat to treat COVID-19 could more quickly save lives.

Realising this, Dr Bobojon Nazarov, founder of biotech company Latus Therapeutics, while in lockdown, identified key studies showing that camostat prevents coronavirus from entering the host cell. He was keen to quickly set up a clinical trial to see if camostat could be used to effectively treat people with COVID-19.

Working with a team of scientists and clinicians from the Universities of Oxford and Edinburgh, he approached the team at the CDD who, realising the potential of camostat, adapted their processes, expedited protocol development and set up activities to help get the trial off the ground.

The CDD team together with Latus Therapeutics also navigated the complex logistics while the world was moving towards lockdown and quickly secured shipping of camostat from Ono Pharmaceutical Co., Ltd., the company that makes it in Japan.***

Latus Therapeutics was instrumental in setting up the research project and securing £1m funding from LifeArc for a clinical trial to test if camostat is effective at treating patients with COVID-19. The project will be sponsored and managed by the CDD at no cost to Cancer Research UK.****

Iain Foulkes, executive director of research and innovation at Cancer Research UK, said: “We’re seeing the impact of COVID-19 on cancer patients throughout the country and we have the skills at Cancer Research UK to assist the national effort in helping to beat this virus, and support from LifeArc is critical to this new trial.

“The charity’s Centre for Drug Development has a strong track record in setting up trials quickly, which is a testament to our sector leading ways of working. The team have shown that in these uncertain times they’ve not only managed to continue treatment for all cancer patients on their phase I trials, but also excelled at this challenge and lent their expertise to others in need. Because we know that the sooner we can find ways to minimise the impact of COVID-19, the more quickly we can more fully return to our life saving cancer research.”

Melanie Lee, LifeArc’s CEO, said: “As an independent medical charity with expertise in medical translation, LifeArc could rapidly offer the resources to evaluate proposals and financially support studies with the best chance of improving patient outcomes. We are pleased to support this vital work during the Covid-19 pandemic.” 

Camostat has a proven safety record because it’s already used to treat patients with chronic pancreatitis, a disease that causes severe pain because of an inflamed pancreas.***** This meant it could proceed straight to a phase III clinical trial, to see if it is effective against COVID-19.

The trial will take place in the community, recruiting people with symptoms of COVID-19 that don’t yet need hospital care.****** Those receiving treatment will take daily doses of the tablet and all patients will be assessed daily by telephone and self-report their temperature and blood oxygen levels.******* The objective of the trial is to see if taking camostat early after COVID-19 symptoms begin can stop the infection from getting worse, reducing the need to go to hospital.

Dr Bobojon Nazarov, founder of Latus Therapeutics, said: “Camostat belongs to the only class of drug that has a strong mechanistic basis for blocking entry of the virus into human cells. We believe this drug could be used to reduce the severity of COVID-19 infection, providing much needed time for the body’s immune system to recognise the virus and destroy it. Unlike finding a vaccine, this drug could be used quickly to help people recover from COVID-19.”

Notes to editors

* Hoffmann et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell 2020;181: 271-280.

** Intensive care national audit & research centre. COVID-19 Report. Accessed 28th May 2020.

*** Camostat has been licenced since the 1980s so is currently off patent. If the clinical trial is successful and camostat is licenced as a treatment for COVID-19 then the drug could be made readily available to patients.

**** This study is being supported by a grant from the medical research charity LifeArc, as part of its activities to address the need for new therapies for Covid-19. LifeArc has made £10m available to repurpose existing medicines or those in the late stage of development as this approach offers one of the fastest routes to develop new treatments that could tackle the virus and its impact. Cancer Research UK’s Centre for Drug Development will aim to expedite trial set up activities to open this trial in early June.


***** Camostat is a drug with 30 years of clinical experience in Japan where it is in clinical use for treatment of chronic pancreatitis with a known, acceptable safety profile.

****** Other trials using camostat are currently underway, including a trial at Aarhus University in Denmark. This trial sponsored by Cancer Research UK’s Centre for Drug Development is unique in terms of the dose level being tested.

******* The trial will involve four 200mg doses of camostat a day. Camostat is only licenced in Japan and isn’t currently available in the UK. The dose level for treating chronic pancreatitis is 600mg daily.


About Cancer Research UK’s Centre for Drug Development

Cancer Research UK has an impressive record of developing novel treatments for cancer. The Cancer Research UK Centre for Drug Development has been pioneering the development of new cancer treatments for more than 25 years, taking over 160 potential new anti-cancer agents into clinical trials in patients. It currently has a portfolio of around 20 new anti-cancer agents in preclinical development, Phase I or early Phase II clinical trials. Six of these new agents have made it to market including temozolomide for brain cancer, abiraterone for prostate cancer and rucaparib for ovarian cancer. Two other drugs are in late development Phase III trials.


About Cancer Research UK’s Commercial Partnerships Team

Cancer Research UK is the world’s leading cancer charity dedicated to saving lives through research. Cancer Research UK’s specialist Commercial Partnerships Team works closely with leading international cancer scientists and their institutes to protect intellectual property arising from their research and to establish links with commercial partners. Cancer Research UK’s commercial activity operates through Cancer Research Technology Ltd., a wholly owned subsidiary of Cancer Research UK. It is the legal entity which pursues drug discovery research in themed alliance partnerships and delivers varied commercial partnering arrangements.

Potential partners interested in collaborating with Cancer Research’s Centre for Drug Development please contact  


About Cancer Research UK

  • Cancer Research UK is the world’s leading cancer charity dedicated to saving lives through research.
  • Cancer Research UK’s pioneering work into the prevention, diagnosis and treatment of cancer has helped save millions of lives.
  • Cancer Research UK has been at the heart of the progress that has already seen survival in the UK double in the last 40 years.
  • Today, 2 in 4 people survive their cancer for at least 10 years. Cancer Research UK’s ambition is to accelerate progress so that by 2034, 3 in 4 people will survive their cancer for at least 10 years.
  • Cancer Research UK supports research into all aspects of cancer through the work of over 4,000 scientists, doctors and nurses.
  • Together with its partners and supporters, Cancer Research UK's vision is to bring forward the day when all cancers are cured.

For further information about Cancer Research UK's work or to find out how to support the charity, please call 0300 123 1022 or visit Follow us on Twitter and Facebook.


About Latus Therapeutics Limited


Founded in 2019, is a leading research and experimental development biotech company with a vision to find a cure for B-cell Lymphomas.


Today, in response to the public health crisis, Latus Therapeutics has refocused its efforts to originate not for profit initiative to find a treatment for the patients tested positive with the COVID-19.  At a time when thousands of people around the world are dying every day from the disease and economies are paralysed, this crucial research will utilise existing medicines that have already been shown to prevent the virus from infecting human cells in vitro.


For further information about Latus Therapeutics and the trials please visit or follow us on Twitter and LinkedIn


About LifeArc


LifeArc is a self-funded medical research charity. Our mission is to advance translation of early science into health care treatments or diagnostics that can be taken through to full development and made available to patients. We have been doing this for more than 25 years and our work has resulted in a diagnostic for antibiotic resistance and four licensed medicines.


Our success allows us to explore new approaches to stimulate and fund translation. We have our own drug discovery and diagnostics development facilities, supported by experts in technology transfer and intellectual property who also provide services to other organisations. Our model is built on collaboration, and we partner with a broad range of groups including medical research charities, research organisations, industry and academic scientists. We are motivated by patient need and scientific opportunity.


Two funds help us to invest in external projects for the benefit of patients: our Philanthropic Fund provides grants to support medical research projects focused on the translation of rare diseases research and our Seed Fund is aimed at start-up companies focussed on developing new therapeutics and biological modalities.


Find out more about our work on or follow us on LinkedIn or Twitter.